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宿主来源
Mouse抗原名称
CD56分子别名
Neural cell adhesion molecule 1; N-CAM-1; NCAM-1; NCAM; NCAM1细胞定位
Cell membraneAccession
P13591克隆号
S-3499抗体类型
Mouse mAb抗体同种型
IgG1,k反应种属 ?
RhMk, CyMk, Hu阳性样本
Human peripheral blood lymphocytes纯化方式
Protein G浓度
0.2 mg/ml标记
Alexa Fluor® 488性状
Liquid缓冲体系
PBS, 1% BSA, 0.09% sodium azide
储存条件
12 months from date of receipt / reconstitution, 2 to 8 °C as supplied
应用
FCM
稀释度
应用 稀释度 推荐种属 FCM 1.25μl per million cells in 100μl volume Hu
Neural cell adhesion molecule 1 (NCAM-1), also known as CD56, is a cell adhesion protein belonging to the immunoglobulin superfamily. It is expressed on various cell types including neurons, muscle cells, and immune cells like natural killer (NK) cells. NCAM-1/CD56 plays crucial roles in cell-to-cell and cell-matrix interactions during development and differentiation, regulating processes such as neurogenesis, neurite outgrowth, axonal guidance, and cell migration in the nervous system. In the immune system, it is involved in the expansion of T lymphocytes, B lymphocytes, and NK cells. NCAM-1/CD56 also triggers signaling cascades involving FYN-focal adhesion kinase (FAK), mitogen-activated protein kinase (MAPK), and phosphatidylinositol 3-kinase (PI3K). Additionally, it serves as a biomarker for certain diseases, such as malignant tumors in the nervous system and neuroendocrine carcinoma.
流式分析
Flow cytometric analysis of Human CD56 expression on Human peripheral blood lymphocytes. Human peripheral blood lymphocytes were stained with Alexa Fluor® 647 Mouse Anti-Human CD3 Antibody and either Alexa Fluor® 488 Mouse IgG1, κ Isotype Control (Left panel) or Alexa Fluor® 488 Mouse Anti-Human CD56 Antibody (Right panel) at 1.25 μl/test. Flow cytometry and data analysis were performed using BD FACSymphony™ A1 and FlowJo™ software.
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