Alexa Fluor^® 647 Rat Anti-Mouse CD107a Antibody (S-R668)

CD107a (also known as lysosome-associated membrane protein-1, LAMP-1) is a heavily N- and O-glycosylated type I transmembrane glycoprotein (~120 kDa) that constitutes ~50% of lysosomal membrane proteins and is expressed constitutively in late endosomes/lysosomes but also transiently on the plasma membrane of degranulating cytotoxic T cells, NK cells, mast cells, and other activated cells, where it serves as a widely used functional marker of degranulation; it participates in lysosomal biogenesis, autophagy, cholesterol homeostasis, and the presentation of carbohydrate ligands to selectins, while its surface exposure correlates with cytotoxic activity and it has been implicated in cancer metastasis, adhesion of immune cells to vascular endothelium, and as a marker in lysosomal storage disorders.