PerCP-Cy5.5 Mouse Anti-Human CD11b Antibody (HI11b)
Integrin alpha-M,CD11 antigen-like family member B,CR-3 alpha chain,Cell surface glycoprotein MAC-1 subunit alpha,Leukocyte adhesion receptor MO1,Neutrophil adherence receptor,CR3A,ITGAM
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宿主来源
Mouse抗原名称
CD11b分子别名
Integrin alpha-M; CD11 antigen-like family member B; CR-3 alpha chain; Cell surface glycoprotein MAC-1 subunit alpha; Leukocyte adhesion receptor MO1; Neutrophil adherence receptor; CR3A; ITGAM细胞定位
Cell membraneAccession
P11215克隆号
HI11b抗体类型
Mouse mAb抗体同种型
IgG2b,k反应种属 ?
Hu阳性样本
Human peripheral blood leukocytes纯化方式
Protein A浓度
0.1 mg/ml标记
PerCP-Cy5.5性状
Liquid缓冲体系
PBS, 1% BSA, 0.3% Proclin 300
储存条件
12 months from date of receipt / reconstitution, 2 to 8 °C as supplied
应用
FCM
稀释度
应用 稀释度 推荐种属 FCM 1μl per million cells in 100μl volume Hu
CD11b, also known as integrin alpha M, is a transmembrane glycoprotein that pairs with CD18 to form the Mac-1 integrin, also referred to as complement receptor type 3 (CR3). It is predominantly expressed on the surface of myeloid cells, including monocytes, neutrophils, macrophages, and microglia. CD11b plays a crucial role in mediating cell adhesion and migration, facilitating the interaction between immune cells and their targets. It is involved in phagocytosis, the process by which cells engulf and eliminate foreign particles or debris. Additionally, CD11b acts as a receptor for complement C3bi, mediating complement-coated particle uptake, and it binds to various ligands such as intercellular adhesion molecules (ICAMs) and fibrinogen, contributing to cell-mediated cytotoxicity, chemotaxis, and immune cell activation.
流式分析
Flow cytometric analysis of Human CD11b expression on human peripheral blood leukocytes. Human peripheral blood leukocytes were stained with either PerCP-Cy5.5 Mouse IgG2b, κ Isotype Control (Left panel) or SDT PerCP-Cy5.5 Mouse Anti-Human CD11b Antibody (Right panel) at 1 μl/test treated with True-Stain Monocyte Blocker™. Total viable cells, as determined by Fixable Viability Dye 515 (S0D0013), were used for analysis. Flow cytometry and data analysis were performed using BD FACSymphony™ A1 and FlowJo™ software.
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