Mouse Anti-Human CD1c Antibody (L161)

CD1c is a lipid-presenting, MHC class I-like glycoprotein expressed on dendritic cells and B cells that binds both self and foreign lipids/glycolipids within its deep hydrophobic groove and shuttles them through endosomal compartments to display them to αβ and γδ T cells, thereby bridging innate and adaptive immunity; uniquely, its open F′ pocket can accommodate both lipid tails and peptide moieties of lipopeptides, enabling recognition of mycobacterial antigens such as mannosyl-β1-phosphomycoketide and driving potent IFN-γ responses essential for controlling intracellular pathogens like Mycobacterium tuberculosis.