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宿主来源
Mouse抗原名称
GARP分子别名
Transforming growth factor beta activator LRRC32; Garpin; Glycoprotein A repetitions predominant (GARP); Leucine-rich repeat-containing protein 32; D11S833E; LRRC32细胞定位
Cell membraneAccession
Q14392克隆号
S-3497抗体类型
Mouse mAb抗体同种型
IgG2b,k反应种属 ?
Hu阳性样本
human peripheral blood leukocytes纯化方式
Protein A浓度
0.2 mg/ml标记
Biotin性状
Liquid缓冲体系
PBS pH7.4, 0.03% Proclin 300
储存条件
12 months from date of receipt / reconstitution, 2 to 8 °C as supplied
应用
FCM
稀释度
应用 稀释度 推荐种属 FCM 5μl per million cells in 100μl volume Hu
GARP, or Glycoprotein A Repetitions Predominant, is a transmembrane protein that acts as a critical docking receptor for latent TGF-β on the surface of activated regulatory T cells and platelets, where its 20 leucine-rich repeats form a horseshoe-shaped solenoid that both stabilizes the cytokine in an inactive conformation and licenses subsequent release through integrin-mediated deformation, thereby positioning GARP as a central checkpoint in immune tolerance and a prime therapeutic target in cancer, autoimmunity and fibrosis.
流式分析
Flow cytometric analysis of Human GARP expression on human peripheral blood leukocytes. Human peripheral blood leukocytes were stained with APC Mouse Anti-Human CD41 antibody and either Biotin Mouse IgG2b, κ Isotype Control (Left panel) or SDT Biotin Mouse Anti- Human GARP antibody (Right panel) at 5 μl/test followed by Sav-PE. Flow cytometry and data analysis were performed using BD FACSymphony™ A1 and FlowJo™ software.
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