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Rat抗原名称
CD198分子别名
C-C chemokine receptor type 8; C-C CKR-8; CC-CKR-8; CCR-8; CDw198; Cmkbr8; Ter1; Ccr8细胞定位
Cell membraneAccession
P56484克隆号
S-R626抗体类型
Rat mAb抗体同种型
IgG2b,k反应种属 ?
Ms阳性样本
C57BL/6 mouse thymocytes纯化方式
Protein G浓度
0.2 mg/ml标记
Alexa Fluor® 488性状
Liquid缓冲体系
PBS, 1% BSA, 0.3% Proclin 300
储存条件
12 months from date of receipt / reconstitution, 2 to 8 °C as supplied
应用
FCM
稀释度
应用 稀释度 推荐种属 FCM 5μl per million cells in 100μl volume Ms
CD198, also known as CCR8, is a 41 kD G-protein coupled receptor with seven transmembrane regions, belonging to the C-C chemokine receptor family. It is predominantly expressed in lymphoid tissues, including subsets of T cells, monocytes, macrophages, eosinophils, thymocytes, Langerhans cells, neurons, and vascular smooth muscle cells. CCR8 plays a crucial role in regulating monocyte chemotaxis, thymic cell apoptosis, and the activation, migration, proliferation, and differentiation of lymphocytes. It is also associated with allergic diseases and has been identified as an alternative coreceptor to CD4 for HIV-1 infection. CCR8 binds to chemokines such as CCL1 (I-309) and CCL18 and exhibits high affinity for viral chemokines like vMIP-I, vMIP-II, and vMCC-I.
流式分析
Flow cytometric analysis of Mouse CD198 expression on C57BL/6 mouse thymocytes. C57BL/6 mouse thymocytes were stained with Alexa Fluor® 647 Rat Anti-Mouse CD4 Antibody and either Alexa Fluor® 488 Rat IgG2b, κ Isotype Control (Left panel) or SDT Alexa Fluor® 488 Rat Anti-Mouse CD198 Antibody (Right panel) at 5μl/test. Flow cytometry and data analysis were performed using BD FACSymphony™ A1 and FlowJo™ software.
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