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宿主来源
Armenian hamster抗原名称
CD61分子别名
Integrin beta-3; Platelet membrane glycoprotein IIIa (GPIIIa); Itgb3细胞定位
Cell membrane, SynapseAccession
O54890克隆号
2C9.G2抗体类型
Recombinant mAb抗体同种型
IgG反应种属 ?
Ms, Rt阳性样本
C57BL/6 mouse bone marrow纯化方式
Protein G浓度
0.2 mg/ml标记
PE性状
Liquid缓冲体系
PBS, 1% BSA, 0.3% Proclin 300
储存条件
12 months from date of receipt / reconstitution, 2 to 8 °C as supplied
应用
FCM
稀释度
应用 稀释度 推荐种属 FCM 5μl per million cells in 100μl volume Ms, Rt
CD61, also known as integrin β3, is a 90-92 kDa type I transmembrane glycoprotein that dimerizes with integrin αIIb (CD41) to form the platelet fibrinogen receptor GPIIb/IIIa or with integrin αV (CD51) to form the vitronectin receptor, and plays a pivotal role in platelet aggregation, clot retraction, angiogenesis, and the adhesion and migration of osteoclasts, smooth muscle cells and tumor cells via recognition of RGD motifs in ligands such as fibrinogen, fibronectin, von Willebrand factor, vitronectin and thrombospondin.
流式分析
Flow cytometric analysis of CD61 expression on C57BL/6 mouse bone marrow. C57BL/6 mouse bone marrow cells were stained with Alexa Fluor® 488 Rat Anti-Mouse TER-119/Erythroid Cells Antibody (S0B5893) and either PE Armenian hamster IgG Isotype Control (Left panel) or SDT PE Armenian hamster Anti-Mouse/Rat CD61 Antibody (Right panel) at 5 μl/test. Total viable cells, as determined by Fixable Viability Dye 452 (S0D0021), were used for analysis. Flow cytometry and data analysis were performed using BD FACSymphony™ A1 and FlowJo™ software.
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