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宿主来源
Mouse抗原名称
CD161分子别名
Killer cell lectin-like receptor subfamily B member 1; C-type lectin domain family 5 member B; HNKR-P1a (NKR-P1A); Natural killer cell surface protein P1A; CLEC5B; NKRP1A; KLRB1细胞定位
MembraneAccession
Q12918克隆号
S-R581抗体类型
Mouse mAb抗体同种型
IgG1,k反应种属 ?
Hu阳性样本
Human PBMC纯化方式
Protein G浓度
0.2 mg/ml标记
Pacific Blue性状
Liquid缓冲体系
PBS, 1% BSA, 0.3% Proclin 300
储存条件
12 months from date of receipt / reconstitution, 2 to 8 °C as supplied
应用
FCM
稀释度
应用 稀释度 推荐种属 FCM 1.25μl per million cells in 100μl volume Hu
CD161 is a C-type lectin-like type II transmembrane protein expressed on natural killer (NK) cells and subsets of T cells, where it functions as an inhibitory receptor on NK cells to suppress cytotoxicity and cytokine secretion, while on T cells it acts as a costimulatory receptor that enhances responsiveness to T-cell receptor (TCR) stimulation by interacting with its ligand LLT1 and is associated with improved survival in various cancers due to its role in amplifying TCR signaling and promoting rapid effector functions.
流式分析
Flow cytometric analysis of Human CD161 expression on human PBMC (human peripheral blood mononuclear cells). Human PBMC were stained with Alexa Fluor® 647 Mouse Anti-Human CD4 Antibody and either Pacific Blue Mouse IgG1, κ Isotype Control (Left panel) or SDT Pacific Blue Mouse Anti-Human CD161 Antibody (Right panel) at 1.25μl/test. Flow cytometry and data analysis were performed using BD FACSymphony™ A1 and FlowJo™ software.
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