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宿主来源
Armenian hamster抗原名称
CD196分子别名
C-C chemokine receptor type 6; C-C CKR-6; CC-CKR-6; CCR-6; KY411; Cmkbr6; Ccr6细胞定位
Cell membraneAccession
O54689克隆号
S-R621抗体类型
Recombinant mAb抗体同种型
IgG反应种属 ?
Ms阳性样本
C57BL/6 mouse splenocytes纯化方式
Protein G浓度
0.2 mg/ml标记
Biotin性状
Liquid缓冲体系
PBS pH7.4, 0.03% Proclin 300
储存条件
12 months from date of receipt / reconstitution, 2 to 8 °C as supplied
应用
FCM
稀释度
应用 稀释度 推荐种属 FCM 5μl per million cells in 100μl volume Ms
CD196, also known as CCR6, is a ~42 kDa G protein-coupled seven-transmembrane chemokine receptor expressed on immature dendritic cells, memory T and B cells, NK cells and Langerhans cells; it binds the unique ligand CCL20 (MIP-3α), triggering calcium signaling that directs chemotactic recruitment of these cells to epithelial and inflamed tissues, thereby orchestrating mucosal immunity, Th17 and regulatory T-cell differentiation, B-lineage maturation, and pathogenic inflammatory circuits in diseases such as psoriasis, rheumatoid arthritis and inflammatory bowel disease.
流式分析
Flow cytometric analysis of Mouse CD196 expression on C57BL/6 mouse splenocytes. C57BL/6 mouse splenocytes were stained with Pacific Blue™ Rat Anti-Mouse CD45R/B220 Antibody and either Biotin Armenian hamster IgG Isotype Control (Left panel) or SDT Biotin Armenian hamster Anti-Mouse CD196 Antibody (Right panel) at 5μl/test followed by Sav-PE. Flow cytometry and data analysis were performed using BD FACSymphony™ A1 and FlowJo™ software.
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