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APC Mouse Anti-Human CD257 Antibody (S-3021)

Tumor necrosis factor ligand superfamily member 13B,B lymphocyte stimulator (BLyS),B-cell-activating factor,BAFF,Dendritic cell-derived TNF-like molecule,TNF- and APOL-related leukocyte expressed ligand 1 (TALL-1),BLYS,TALL1,TNFSF20,ZTNF4,TNFSF13B

价格 ￥1,100.00 （ 供应商现货 ： 3-5个工作日）
货号 S0B8261
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产品介绍

产品介绍 评论(0)

产品规格

  • 宿主来源

    Mouse

  • 抗原名称

    CD257

  • 分子别名

    Tumor necrosis factor ligand superfamily member 13B; B lymphocyte stimulator (BLyS); B-cell-activating factor; BAFF; Dendritic cell-derived TNF-like molecule; TNF- and APOL-related leukocyte expressed ligand 1 (TALL-1); BLYS; TALL1; TNFSF20; ZTNF4; TNFSF13B

  • 细胞定位

    Cell membrane

  • Accession

    Q9Y275

  • 克隆号

    S-3021

  • 抗体类型

    Mouse mAb

  • 抗体同种型

    IgG2a,k

  • 反应种属 ?

    Hu

  • 阳性样本

    U-937

  • 纯化方式

    Protein A

  • 浓度

    0.2 mg/ml

  • 标记

    APC

  • 性状

    Liquid

  • 缓冲体系

    PBS, 1% BSA, 0.3% Proclin 300

  • 储存条件

    12 months from date of receipt / reconstitution, 2 to 8 °C as supplied

  • 应用

    FCM

  • 稀释度

    应用 稀释度 推荐种属
    FCM 1.25μl per million cells in 100μl volume Hu
背景介绍

  • CD257 is a 285-aa type-II transmembrane glycoprotein of the TNF ligand superfamily produced by monocytes, dendritic cells, macrophages and activated T cells that can be cleaved to a soluble homotrimeric cytokine which, via engagement of three receptors—BAFF-R, TACI and BCMA—delivers survival and maturation signals to B cells, orchestrates T-cell co-stimulation, and drives class-switching and antibody production through NF-κB and PI3K/AKT pathways, while excess CD257 triggers B-cell hyperplasia and autoantibody formation, linking its overexpression to systemic lupus erythematosus, Sjögren syndrome, rheumatoid arthritis and multiple myeloma, and making CD257 antagonism (e.g., belimumab) a validated therapeutic strategy.

  • 流式分析

    • Flow cytometric analysis of Human CD257 expression on U-937 cells. Cells from the Daudi (Human Burkitt's lymphoma lymphoblast, Left) / U-937 (Human histiocytic lymphoma monocyte, Right) labelling SDT APC Mouse Anti-Human CD257 Antibody at 1.25 μl/test / (Red line histogram) compared with a APC Mouse IgG2a, κ (Black line histogram) isotype control. Flow cytometry and data analysis were performed using BD FACSymphony™ A1 and FlowJo™ software. Negative control: Daudi

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