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分子别名
Thrombomodulin; TM; Fetomodulin; THRM; THBD细胞定位
MembraneAccession
P07204克隆号
S-2870抗体类型
Mouse mAb抗体同种型
IgG1,k反应种属 ?
Hu纯化方式
Protein G浓度
0.2 mg/ml标记
PerCP-Cy5.5性状
Liquid缓冲体系
PBS, 1% BSA, 0.3% Proclin 300
储存条件
12 months from date of receipt / reconstitution, 2 to 8 °C as supplied
应用
FCM
稀释度
应用 稀释度 推荐种属 FCM 5μl per million cells in 100μl volume Hu
CD141, also known as thrombomodulin, is a 75 kDa single-chain type I membrane glycoprotein that serves as a crucial cofactor in the protein C anticoagulant system. It is expressed on various cell types, including endothelial cells, monocytes, dendritic cells, and keratinocytes. When thrombin binds to CD141, it activates protein C, which degrades clotting factors Va and VIIIa, thereby reducing thrombin generation and preventing excessive blood coagulation. Additionally, CD141 is involved in embryonic development and atherosclerotic plaque formation. In the immune system, CD141+ dendritic cells have been shown to produce significant amounts of IFN-α in response to certain stimuli, indicating their important role in immune responses.
流式分析
Flow cytometric analysis of Human CD141 expression on human PBMC (human peripheral blood mononuclear cell). Human PBMC were stained with either PerCP-Cy5.5 Mouse IgG1, κ Isotype Control (Left panel) or SDT PerCP-Cy5.5 Mouse Anti-Human CD141 Antibody (Right panel) at 5 μl/test treated with True-Stain Monocyte Blocker™. Total viable cells, as determined by Fixable Viability Dye 515 (S0D0013), were used for analysis. Flow cytometry and data analysis were performed using BD FACSymphony™ A1 and FlowJo™ software.
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