分享产品介绍 评论(0)
分子别名
CD158a; CD158g; CD158h; KIR2DL1; KIR2DS1; KIR2DS3; KIR2DS5细胞定位
Cell membraneAccession
P43626, Q14953, Q14954克隆号
S-2918抗体类型
Mouse mAb抗体同种型
IgG2b,k反应种属 ?
Hu纯化方式
Protein A浓度
0.2 mg/ml标记
FITC性状
Liquid缓冲体系
PBS, 1% BSA, 0.3% Proclin 300
储存条件
12 months from date of receipt / reconstitution, 2 to 8 °C as supplied
应用
FCM
稀释度
应用 稀释度 推荐种属 FCM 5μl per million cells in 100μl volume Hu
CD158, also known as killer-cell immunoglobulin-like receptor (KIR), is a polymorphic type I transmembrane glycoprotein expressed chiefly on natural killer (NK) cells and subsets of T cells that recognizes specific HLA class I allotypes (HLA-A, -B or -C) and transmits either inhibitory or activating signals—depending on whether its cytoplasmic tail contains ITIMs or associates with the ITAM-bearing adaptor DAP12—to regulate cytotoxic activity, thereby serving as a critical immune checkpoint whose blockade is being explored clinically to unleash NK-cell mediated anti-tumor responses.
流式分析
Flow cytometric analysis of Human CD158 expression on Human PBMC (human peripheral blood mononuclear cells). Human PBMC were stained with APC Mouse Anti-Human CD56 antibody and either FITC Mouse IgG2b, κ Isotype Control (Left panel) or SDT FITC Mouse Anti- Human CD158 antibody (Right panel) at 5 μl/test. Flow cytometry and data analysis were performed using BD FACSymphony™ A1 and FlowJo™ software.
评论(0)