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分子别名
Membrane cofactor protein; TLX; Trophoblast leukocyte common antigen; MCP; MIC10; CD46Accession
P15529克隆号
S-3061抗体类型
Mouse mAb抗体同种型
IgG2a,k反应种属 ?
Hu纯化方式
Protein A浓度
0.2 mg/ml标记
FITC性状
Liquid缓冲体系
PBS, 1% BSA, 0.3% Proclin 300
储存条件
12 months from date of receipt / reconstitution, 2 to 8 °C as supplied
应用
FCM
稀释度
应用 稀释度 推荐种属 FCM 5μl per million cells in 100μl volume Hu
CD46, also known as membrane cofactor protein (MCP), is a type I transmembrane glycoprotein expressed on almost all human nucleated cells that protects host tissues from complement-mediated injury by acting as a cofactor for factor I–mediated proteolytic inactivation of the complement fragments C3b and C4b, and also modulates adaptive immunity by driving IFN-γ–biased Th1 responses and subsequent IL-10–producing T-regulatory cell differentiation, while serving as a cellular receptor for multiple pathogens including measles virus, adenoviruses, HHV-6, and pathogenic Neisseria.
流式分析
Flow cytometric analysis of Human CD46 expression on Human PBMC (human peripheral blood mononuclear cells). Human PBMC were stained with either FITC Mouse IgG2a, κ Isotype Control (Black line histogram) or SDT FITC Mouse Anti-Human CD46 Antibody (Red line histogram) at 5 μl/test. Flow cytometry and data analysis were performed using BD FACSymphony™ A1 and FlowJo™ software.
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