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分子别名
Endoglin; END; ENG免疫原
Recombinant Protein细胞定位
Cell membraneAccession
P17813克隆号
S-837-10抗体类型
Mouse mAb抗体同种型
IgG2b,k反应种属 ?
Hu纯化方式
Protein A浓度
0.2 mg/ml标记
APC-Cy7性状
Liquid缓冲体系
PBS, 1% BSA, 0.3% Proclin 300
储存条件
12 months from date of receipt / reconstitution, 2 to 8 °C as supplied
应用
FCM
稀释度
应用 稀释度 推荐种属 FCM 5μl per million cells in 100μl volume Hu
CD105, also known as endoglin, is a type I transmembrane glycoprotein predominantly expressed on endothelial cells and serves as an accessory receptor for the transforming growth factor-beta (TGF-β) superfamily. It plays a crucial role in angiogenesis, making it a key factor in tumor growth, survival, and metastasis. Structurally, CD105 is a homodimeric protein with a large extracellular domain, a hydrophobic transmembrane region, and a short cytoplasmic tail. Its expression is upregulated in proliferating endothelial cells, especially in tumor vessels, inflamed tissues, and during embryogenesis. Mutations in the CD105 gene are associated with hereditary hemorrhagic telangiectasia (HHT), a disorder characterized by abnormal blood vessel formation. Due to its involvement in angiogenesis, CD105 has emerged as a potential therapeutic target for cancer treatment.
流式分析
Flow cytometric analysis of Human CD105 expression on Human PBMC (human peripheral blood mononuclear cells). Human PBMC were stained with either APC-Cy7 Mouse IgG2b, κ Isotype Control (Left panel) or SDT APC-Cy7 Mouse Anti-Human CD105 antibody (Right panel) at 5μl/test treated with True-Stain Monocyte Blocker™. Flow cytometry and data analysis were performed using BD FACSymphony™ A1 and FlowJo™ software.
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