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宿主来源
Armenian hamster分子别名
T-lymphocyte activation antigen CD80; Activation B7-1 antigen (B7); B7; Cd80细胞定位
Cell membraneAccession
Q00609克隆号
16-10A1抗体类型
Recombinant mAb抗体同种型
IgG反应种属 ?
Ms纯化方式
Protein G浓度
0.2 mg/ml标记
Alexa Fluor® 488性状
Liquid缓冲体系
PBS, 1% BSA, 0.3% Proclin 300
储存条件
12 months from date of receipt / reconstitution, 2 to 8 °C as supplied
应用
FCM
稀释度
应用 稀释度 推荐种属 FCM 5μl per million cells in 100μl volume Ms
CD80, also known as B7-1, is a co - stimulatory molecule expressed on antigen - presenting cells (APCs) such as dendritic cells, macrophages and B cells. It plays a crucial role in the immune response by interacting with CD28 on T cells to provide a co - stimulatory signal necessary for T cell activation, thereby promoting T cell proliferation and differentiation. Additionally, CD80 can also bind to CTLA - 4, an inhibitory receptor on T cells, which acts as a negative regulator of T cell activation. This binding can inhibit the immune response and maintain immune tolerance. Moreover, CD80 - CD28 interaction is involved in the regulation of various immune - related processes, including the formation of immunological synapses and the regulation of cytokine production.
流式分析
Flow cytometric analysis of mouse CD80 expression on C57BL/6 mouse splenocytes treated with LPS. C57BL/6 mouse splenocytes (Left) or treated with LPS (500ng/ml, 3d) (Right) were stained with SDT Alexa Fluor® 488 Armenian hamster Anti-Mouse CD80 antibody at 5 μl/test. Flow cytometry and data analysis were performed using BD FACSymphony™ A1 and FlowJo™ software.
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