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宿主来源
Mouse抗原名称
CX3CR1分子别名
CX3C chemokine receptor 1; C-X3-C CKR-1; mCX3CR1; Fractalkine receptor细胞定位
Cell membraneAccession
Q9Z0D9克隆号
S-R597抗体类型
Mouse mAb抗体同种型
IgG2a,k反应种属 ?
Ms阳性样本
C57BL/6 mouse bone marrow纯化方式
Protein A浓度
0.2 mg/ml标记
Biotin性状
Liquid缓冲体系
PBS pH7.4, 0.03% Proclin 300
储存条件
12 months from date of receipt / reconstitution, 2 to 8 °C as supplied
应用
FCM
稀释度
应用 稀释度 推荐种属 FCM 5μl per million cells in 100μl volume Ms
CX3CR1 is a seven-transmembrane G-protein-coupled receptor expressed on monocytes, macrophages, dendritic cells, microglia and tissue-patrolling lymphocytes that serves as the exclusive receptor for the unique membrane-tethered or soluble chemokine CX3CL1 (fractalkine), thereby orchestrating leukocyte adhesion, chemotaxis and survival during development, homeostasis, viral and bacterial infections, inflammatory diseases such as atherosclerosis and rheumatoid arthritis, neuroinflammatory conditions including Alzheimer’s disease, and tumor progression or metastasis, while also acting as a co-receptor for respiratory syncytial virus entry into airway epithelium and modulating antiviral immunity via IL-10 induction.
流式分析
Flow cytometric analysis of Mouse CX3CR1 expression on C57BL/6 mouse bone marrow. C57BL/6 mouse bone marrow was stained with Brilliant Violet 421™ Rat Anti-Mouse CD11b antibody and either Biotin Mouse IgG2a, κ Isotype Control (Left panel) or SDT Biotin Mouse Anti-Mouse CX3CR1 Antibody (Right panel) at 5 μl/test followed by Sav-PE. Flow cytometry and data analysis were performed using BD FACSymphony™ A1 and FlowJo™ software.
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