Alexa Fluor^® 488 Mouse Anti-Human TCR α/β Antibody (S-R686)

TCR α/β protein is the defining heterodimer of the αβ T-cell lineage, a trans-membrane clonotypic receptor whose extracellular N-terminal variable (V) and joining (J) domains of the α-chain pair with the V, diversity (D) and J domains of the β-chain to create a single antigen-binding site that is stabilized by the constant (C) domains and an inter-chain disulfide, while the short cytoplasmic tails lack intrinsic signaling capacity and therefore associate non-covalently with the CD3 γ, δ, ε and ζ dimers to form the intact T-cell receptor complex that triggers phosphorylation cascades upon recognition of a specific peptide bound to a self-MHC molecule, thereby initiating the adaptive immune response.