Alexa Fluor^® 488 Mouse Anti-Human CD6 Antibody (S-3174)

CD6 is a type I transmembrane glycoprotein primarily expressed on the surface of T cells and a subset of B cells, belonging to the scavenger receptor superfamily. Its structure comprises three scavenger receptor cysteine-rich (SRCR) domains, a proline-rich spacer region, and a cytoplasmic tail containing multiple conserved signaling motifs. By interacting with its ligand CD166 (ALCAM), which is expressed on antigen-presenting cells, CD6 directly participates in the regulation of T cell activation, proliferation, migration, and differentiation. As a co-stimulatory molecule in the T cell receptor signaling pathway, CD6 not only enhances T cell sensitivity to antigens but also influences immune tolerance by modulating thymocyte selection. In recent years, CD6 has emerged as a therapeutic target for autoimmune diseases such as multiple sclerosis, where monoclonal antibodies targeting the CD6-CD166 pathway can inhibit excessive immune responses, highlighting its critical role in immune regulation.