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宿主来源
Mouse抗原名称
CD155/PVR分子别名
Poliovirus receptor; Nectin-like protein 5 (NECL-5); PVS细胞定位
Cell membraneAccession
P15151克隆号
SKII.4抗体类型
Mouse mAb抗体同种型
IgG1,k同型对照
S0B1542反应种属 ?
Hu阳性样本
U-937纯化方式
Protein G浓度
0.2 mg/ml标记
Pacific Blue性状
Liquid缓冲体系
PBS, 1% BSA, 0.09% sodium azide
储存条件
12 months from date of receipt / reconstitution, 2 to 8 °C as supplied
应用
FCM
稀释度
应用 稀释度 推荐种属 FCM 5μl per million cells in 100μl volume Hu
CD155, also designated PVR (poliovirus receptor) and Necl-5, is a ~70 kDa primate-restricted type I transmembrane glycoprotein of the immunoglobulin superfamily that contains one V-type and two C2-type extracellular Ig-like domains, a 24-aa transmembrane segment and a 50-aa cytoplasmic tail; it serves as the cellular entry receptor for poliovirus, mediates cell adhesion by binding vitronectin and nectin-3, and engages immune receptors DNAM-1/CD226, CD96 and TIGIT to regulate NK-cell cytotoxicity, T-cell activation and tumor-cell recognition, while its expression—up-regulated by IFN-γ on endothelial cells and abundant on immature thymocytes, dendritic cells and epithelial/neuronal tumor cells—promotes cell migration, loss of contact inhibition and transendothelial migration.
流式分析
Flow cytometric analysis of CD155 expression on U-937 (Human histiocytic lymphoma monocyte, right) / Raji (Human Burkitt's lymphoma B lymphocyte, left). U-937 cells and Raji cells were stained with either Pacific Blue Mouse IgG1, k Isotype Control (black line histogram) or SDT Pacific Blue Mouse Anti-Human CD155 Antibody (red line histogram) at 5 μl/test. Flow cytometry and data analysis were performed using Agilent NovoCyte Quanteon and FlowJo™ software.
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