Alexa Fluor® 488 Mouse Anti-Human/Mouse CXCR7 Antibody (S-3127)
Atypical chemokine receptor 3,C-X-C chemokine receptor type 7 (CXC-R7,CXCR-7),Chemokine orphan receptor 1,G-protein coupled receptor 159,G-protein coupled receptor RDC1 homolog (RDC-1),CMKOR1,GPR159,RDC1,ACKR3
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宿主来源
Mouse抗原名称
CXCR7分子别名
Atypical chemokine receptor 3; C-X-C chemokine receptor type 7 (CXC-R7; CXCR-7); Chemokine orphan receptor 1; G-protein coupled receptor 159; G-protein coupled receptor RDC1 homolog (RDC-1); CMKOR1; GPR159; RDC1; ACKR3细胞定位
Cell membrane, EndosomeAccession
P25106, P56485克隆号
S-3127抗体类型
Mouse mAb抗体同种型
IgG2b,k同型对照
S0B1580反应种属 ?
Hu, Ms阳性样本
CXCR7 transfected 293F纯化方式
Protein A浓度
0.5 mg/ml标记
Alexa Fluor® 488性状
Liquid缓冲体系
PBS, 1% BSA, 0.09% sodium azide
储存条件
12 months from date of receipt / reconstitution, 2 to 8 °C as supplied
应用
FCM
稀释度
应用 稀释度 推荐种属 FCM 1μg per million cells in 100μl volume Hu, Ms
CXCR7, also known as ACKR3, is an atypical chemokine receptor that binds the inflammatory ligands CXCL11 and CXCL12 with high affinity but signals through β-arrestin rather than classical G-proteins, thereby functioning as a scavenger to shape chemokine gradients and modulate CXCR4-mediated responses; it is broadly expressed in vascular endothelium, tumor cells, and immune tissues, where it regulates angiogenesis, tumor metastasis, stem-cell trafficking, and cardiac development, and its dysregulation has been implicated in cancer progression, autoimmune disorders, and cardiovascular disease, making it a promising diagnostic marker and therapeutic target.
流式分析
Flow cytometric analysis of 293F (Human embryonic kidney epithelial cell, left) / CXCR7 transfected 293F (Human T cell leukemia T lymphocyte, right) stained with SDT Alexa Fluor® 488 Mouse Anti-Human CXCR7 Antibody at 2 μl/test. Flow cytometry and data analysis were performed using BD FACSymphony™ A1 and FlowJo™ software.
Negative control: 293F
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