Biotin Rat Anti-Mouse CD204 Antibody (S-R712)

CD204, also known as scavenger receptor A, is a type of class A scavenger receptor that is a transmembrane protein with homotrimeric structures. It is primarily expressed on macrophages and dendritic cells, and is involved in a variety of physiological and pathological processes. CD204 can bind to a broad range of ligands, including chemically modified or altered molecules, bacterial surface components, apoptotic cells, and endogenous danger molecules such as stress protein. It plays a significant role in atherosclerosis as it was the first receptor identified for modified lipoproteins that are pertinent to the development of vascular disease. In addition, CD204 has been found to have regulatory functions in the immune response, such as suppressing the dimerization and autoubiquitination of TRAF6, and dampening the immunostimulatory adjuvant activities derived from damage-associated molecular patterns or pathogen-associated molecular patterns.