Biotin Mouse Anti-Human CD371 Antibody (S-2850)
C-type lectin domain family 12 member A,C-type lectin-like molecule 1 (CLL-1),Dendritic cell-associated lectin 2 (DCAL-2),Killer cell C-type lectin-like receptor L1 (hKLRL1),Myeloid inhibitory C-type lectin-like receptor (MICL),CLL1,DCAL2,KLRL1,MICL,CLEC12A
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宿主来源
Mouse抗原名称
CD371分子别名
C-type lectin domain family 12 member A; C-type lectin-like molecule 1 (CLL-1); Dendritic cell-associated lectin 2 (DCAL-2); Killer cell C-type lectin-like receptor L1 (hKLRL1); Myeloid inhibitory C-type lectin-like receptor (MICL); CLL1; DCAL2; KLRL1; MICL; CLEC12A细胞定位
Cell membraneAccession
Q5QGZ9克隆号
S-2850抗体类型
Mouse mAb抗体同种型
IgG2a,k同型对照
S0B5432反应种属 ?
Hu阳性样本
Human peripheral blood cells纯化方式
Protein G浓度
0.2 mg/ml标记
Biotin性状
Liquid缓冲体系
PBS pH7.4, 0.09% sodium azide
储存条件
12 months from date of receipt / reconstitution, 2 to 8 °C as supplied
应用
FCM
稀释度
应用 稀释度 推荐种属 FCM 5μl per million cells in 100μl volume Hu
CD371, also known as CLEC12A, is a type II transmembrane protein with extracellular C-type lectin domains, primarily expressed on myeloid cells. It is a potential myeloid cancer stem cell marker and is considered a target for antibody-based or chimeric antigen receptor T-cell therapies. CD371 is particularly associated with DUX4-rearranged leukemia, where it is highly expressed and serves as a unique cell surface marker. Its expression is also linked to “switch” acute lymphoblastic leukemia (ALL), which has a tendency to switch to monocyte-like cells upon corticosteroid treatment.
流式分析
Flow cytometric analysis of CD371 expression on human Peripheral Blood cells. Human Peripheral Blood cells were stained with either Biotin Mouse IgG2a, k Isotype Control (left panel) or SDT Biotin Mouse Anti-Human CD371 Antibody (right panel) at 5 μl/test followed by Sav-iFluor 488. Flow cytometry and data analysis were performed using Agilent NovoCyte Quanteon and FlowJo™ software.
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