PerCP-Cy5.5 Mouse Anti-Human CD172a/b Antibody (S-3431)
Tyrosine-protein phosphatase non-receptor type substrate 1,SHP substrate 1,SHPS-1,Brain Ig-like molecule with tyrosine-based activation motifs (Bit),CD172 antigen-like family member A,Inhibitory receptor SHPS-1,Macrophage fusion receptor,MyD-1 antigen,Signal-regulatory protein alpha-1 (Sirp-alpha-1),Signal-regulatory protein alpha-2 (Sirp-alpha-2),Signal-regulatory protein alpha-3 (Sirp-alpha-3),p84,SIRPA,BIT,MFR,MYD1,PTPNS1,SHPS1,SIRP Signal-regulatory protein beta-1,SIRP-beta-1,CD172 antigen-like family member B,CD172b,SIRPB1
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宿主来源
Mouse抗原名称
CD172a/b分子别名
Tyrosine-protein phosphatase non-receptor type substrate 1; SHP substrate 1; SHPS-1; Brain Ig-like molecule with tyrosine-based activation motifs (Bit); CD172 antigen-like family member A; Inhibitory receptor SHPS-1; Macrophage fusion receptor; MyD-1 antigen; Signal-regulatory protein alpha-1 (Sirp-alpha-1); Signal-regulatory protein alpha-2 (Sirp-alpha-2); Signal-regulatory protein alpha-3 (Sirp-alpha-3); p84; SIRPA; BIT; MFR; MYD1; PTPNS1; SHPS1; SIRP Signal-regulatory protein beta-1; SIRP-beta-1; CD172 antigen-like family member B; CD172b; SIRPB1细胞定位
Cell membraneAccession
O00241, P78324克隆号
S-3431抗体类型
Mouse mAb抗体同种型
IgG1,k同型对照
S0B1582反应种属 ?
Hu阳性样本
Human peripheral blood leukocytes纯化方式
Protein G浓度
0.2 mg/ml标记
PerCP-Cy5.5性状
Liquid缓冲体系
PBS, 1% BSA, 0.09% sodium azide
储存条件
12 months from date of receipt / reconstitution, 2 to 8 °C as supplied
应用
FCM
稀释度
应用 稀释度 推荐种属 FCM 5μl per million cells in 100μl volume Hu
CD172a (SIRPα) and CD172b (SIRPβ1) are paired immunoglobulin-superfamily transmembrane glycoproteins that regulate myeloid-cell activation: CD172a binds CD47 to deliver inhibitory “don’t-eat-me” signals via SHP-1/2 phosphatases, controlling phagocytosis and dendritic-cell homeostasis, whereas CD172b lacks CD47 affinity and instead partners with the adaptor DAP12 to recruit SYK kinase and provide activating cues during innate immune responses.
流式分析
Flow cytometric analysis of Human CD172a/b expression on human peripheral blood leukocytes. Human peripheral blood leukocytes were stained with either PerCP-Cy5.5 Mouse IgG1, κ Isotype Control (left panel) or SDT PerCP-Cy5.5 Mouse Anti-Human CD172a/b Antibody (right panel) at 5 μl/test. Total viable cells, as determined by Fixable Viability Dye 452 (S0B88801), were used for analysis. Flow cytometry and data analysis were performed using Agilent NovoCyte Quanteon and FlowJo™ software.
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