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宿主来源
Mouse抗原名称
CD5分子别名
T-cell surface glycoprotein CD5; Lymphocyte antigen T1/Leu-1; LEU1细胞定位
Cell membraneAccession
P06127克隆号
UCHT2抗体类型
Mouse mAb抗体同种型
IgG1,k同型对照
S0B80038反应种属 ?
Hu阳性样本
Human peripheral blood leukocytes纯化方式
Protein G浓度
0.2 mg/ml标记
APC性状
Liquid缓冲体系
PBS, 1% BSA, 0.09% sodium azide
储存条件
12 months from date of receipt / reconstitution, 2 to 8 °C as supplied
应用
FCM
稀释度
应用 稀释度 推荐种属 FCM 5μl per million cells in 100μl volume Hu
CD5 is a 67 kDa type I cell surface glycoprotein that belongs to the scavenger receptor cysteine-rich (SRCR) family. It is expressed on all T cells and a subset of B cells known as B-1a cells. CD5 plays a crucial role in regulating T cell receptor (TCR) signaling and acts as a negative regulator of T cell activation. It helps fine-tune the threshold for T cell activation during thymocyte development and suppresses peripheral T cell activation by inhibiting TCR-proximal signaling. In B-1a cells, CD5 helps prevent self-reactivity by dampening B cell receptor (BCR) signals. The expression of CD5 is also associated with cell survival, apoptosis, and the development of regulatory T cells. Additionally, CD5 may be involved in the regulation of dendritic cell function and cytokine production.
流式分析
Flow cytometric analysis of Human CD5 expression on human peripheral blood leukocytes. Human peripheral blood leukocytes were stained with Super Bright™ 436 Mouse Anti-Human CD19 Antibody and either APC Mouse IgG1, k Isotype Control (left panel) or SDT APC Mouse Anti-Human CD5 Antibody (right panel) at 5 μl/test. Flow cytometry and data analysis were performed using Agilent NovoCyte Quanteon and FlowJo™ software.
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