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宿主来源
Mouse抗原名称
CD99分子别名
CD99 antigen; 12E7; E2 antigen; Protein MIC2; T-cell surface glycoprotein E2; MIC2; MIC2X; MIC2Y细胞定位
MembraneAccession
P14209克隆号
S-R646抗体类型
Mouse mAb抗体同种型
IgG2a,k同型对照
S0B8029反应种属 ?
Hu阳性样本
Human Peripheral Blood cells纯化方式
Protein A浓度
0.1 mg/ml标记
Alexa Fluor® 488性状
Liquid缓冲体系
PBS, 1% BSA, 0.09% sodium azide
储存条件
12 months from date of receipt / reconstitution, 2 to 8 °C as supplied
应用
FCM
稀释度
应用 稀释度 推荐种属 FCM 2μl per million cells in 100μl volume Hu
CD99, also known as MIC2 or single-chain type-1 glycoprotein, is a heavily O-glycosylated transmembrane protein encoded by the CD99 gene. It is widely expressed in various cell types, including hematopoietic cells, endothelial cells, and many types of cancer cells. This protein plays crucial roles in multiple biological processes such as cell adhesion, migration, differentiation, and apoptosis. In the immune system, CD99 is involved in T-cell activation, maturation, and the regulation of leukocyte transmigration. It also has a significant impact on tumor biology, as it is often overexpressed in cancers like Ewing sarcoma and certain leukemias. Engagement of CD99 by specific antibodies can induce caspase-independent cell death in tumor cells, making it a potential therapeutic target.
流式分析
Flow cytometric analysis of CD99 expression on human peripheral blood leukocytes. Human peripheral blood leukocytes were stained with either Alexa Fluor® 488 Mouse IgG2a, κ Isotype Control (left panel) or SDT Alexa Fluor® 488 Mouse Anti-Human CD99 Antibody (right panel) at 2 μl/test. Flow cytometry and data analysis were performed using Agilent NovoCyte Quanteon and FlowJo™ software.
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