分享产品介绍 评论(0)
宿主来源
Mouse抗原名称
CD196分子别名
C-C chemokine receptor type 6; C-C CKR-6; CC-CKR-6; CCR-6; Chemokine receptor-like 3 (CKR-L3); DRY6; G-protein coupled receptor 29; GPR-CY4 (GPRCY4); LARC receptor; CKRL3; CMKBR6; GPR29; STRL22; CCR6细胞定位
Cell membraneAccession
P51684克隆号
S-R645抗体类型
Mouse mAb抗体同种型
IgG1,k同型对照
S0B5756反应种属 ?
Hu阳性样本
Human PBMC纯化方式
Protein G浓度
0.2 mg/ml标记
PE性状
Liquid缓冲体系
PBS, 1% BSA, 0.09% sodium azide
储存条件
12 months from date of receipt / reconstitution, 2 to 8 °C as supplied
应用
FCM
稀释度
应用 稀释度 推荐种属 FCM 5μl per million cells in 100μl volume Hu
CD196, also known as CCR6, is a seven-transmembrane G protein-coupled receptor belonging to the beta-chemokine receptor family. It is expressed on B cells, subsets of T cells, dendritic cells, natural killer cells, and Langerhans cells. CD196 binds to its ligand CCL20 (MIP-3α) and plays a key role in regulating the migration and recruitment of immune cells, particularly in inflammatory and immune responses. Additionally, CD196 is involved in the differentiation of Th17 cells and the development of regulatory T cells (CD4+FoxP3+). In pathological contexts, CD196 is associated with various diseases, including autoimmune conditions such as rheumatoid arthritis and inflammatory bowel disease, as well as certain cancers.
流式分析
Flow cytometric analysis of Human CD196 expression on human PBMCs (human peripheral blood mononuclear cells). Human PBMC were stained with Brilliant Violet 421™ Mouse Anti-Human CD19 Antibody and either PE Mouse IgG1, κ Isotype Control (left panel) or SDT PE Mouse Anti-Human CD196 Antibody (right panel) at 5μl/test. Flow cytometry and data analysis were performed using Agilent NovoCyte Quanteon and FlowJo™ software.
评论(0)