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宿主来源
Mouse抗原名称
CD42b分子别名
Platelet glycoprotein Ib alpha chain; GP-Ib alpha; GPIb-alpha; GPIbA; Glycoprotein Ibalpha; Antigen CD42b-alpha; GP1BA细胞定位
MembraneAccession
P07359克隆号
HIP1抗体类型
Mouse mAb抗体同种型
IgG1,k同型对照
S0B5964反应种属 ?
Hu阳性样本
Fresh human peripheral blood cells纯化方式
Protein G浓度
0.2 mg/ml标记
Alexa Fluor® 647性状
Liquid缓冲体系
PBS, 1% BSA, 0.09% sodium azide
储存条件
12 months from date of receipt / reconstitution, 2 to 8 °C as supplied
应用
FCM
稀释度
应用 稀释度 推荐种属 FCM 5μl per million cells in 100μl volume Hu
CD42b, also known as glycoprotein Ib alpha (GPIbα), is a type I transmembrane glycoprotein expressed on platelets and megakaryocytes. It is a key component of the GPIb-IX-V receptor complex, which plays a critical role in platelet adhesion and thrombus formation by binding to von Willebrand factor (vWF) at sites of vascular injury. CD42b interacts with various molecules, including thrombin, coagulation factors XI and XII, and P-selectin, contributing to hemostasis and thrombosis. Mutations or polymorphisms in CD42b are associated with diseases such as Bernard-Soulier syndrome and platelet-type von Willebrand disease.
流式分析
Flow cytometric analysis of human CD42b expression on fresh human peripheral blood cells. Fresh Human peripheral blood cells were stained with FITC Mouse Anti-Human CD41a Antibody and either Alexa Fluor® 647 Mouse IgG1, k Isotype Control (left panel) or SDT Alexa Fluor® 647 Mouse Anti-Human CD42b Antibody (right panel) at 5 μl/test. Flow cytometry and data analysis were performed using Agilent NovoCyte Quanteon and FlowJo™ software.
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