Mouse Anti-Human CD198 (CCR8) Antibody (S-4829)

CD198, also known as C-C chemokine receptor type 8 (CCR8) or CDw198, is a seven-transmembrane G protein-coupled receptor (GPCR) encoded by a gene located on human chromosome 3p21.3, with a molecular weight of approximately 41 kDa. This receptor is primarily expressed on the surface of regulatory T cells (Tregs), thymocytes, Th2-polarized cells, NKT cells, as well as some monocytes/macrophages and dendritic cells. Its high-affinity ligand is CCL1, and upon binding, it mediates chemotaxis to recruit immune cells to inflammatory sites and participates in the regulation of thymocyte apoptosis. In terms of pathophysiology, CD198 exhibits specific high expression on Treg cells within the tumor microenvironment, while its expression is very low in peripheral blood and normal tissues, making it an important target for selectively depleting tumor-infiltrating Tregs and relieving tumor immunosuppression. Additionally, CD198 plays a role in allergic diseases and can serve as a co-receptor for HIV-1 infection. Therefore, antibody drugs targeting CD198—particularly monoclonal antibodies that selectively deplete tumor-infiltrating Tregs through Fc-mediated ADCC activity—are being widely developed as an emerging strategy for next-generation cancer immunotherapy.