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宿主来源
Rat抗原名称
CD106分子别名
Vascular cell adhesion protein 1; V-CAM 1; VCAM-1Cleaved into 1 chainsSoluble Vascular Cell Adhesion Molecule-1; Vcam-1; Vcam1细胞定位
Secreted, Cell membraneAccession
P29533克隆号
S-R733抗体类型
Rat mAb抗体同种型
IgG2a,k同型对照
S0B8044反应种属 ?
Ms阳性样本
C57BL/6 mouse bone marrow纯化方式
Protein G浓度
0.5 mg/ml标记
Alexa Fluor® 647性状
Liquid缓冲体系
PBS, 1% BSA, 0.3% Proclin 300
储存条件
12 months from date of receipt / reconstitution, 2 to 8 °C as supplied
应用
FCM
稀释度
应用 稀释度 推荐种属 FCM 1μg per million cells in 100μl volume Ms
CD106, also known as vascular cell adhesion molecule-1 (VCAM-1), is a member of the immunoglobulin superfamily of proteins and is predominantly expressed in endothelial cells. It is a cytokine-inducible cell surface protein capable of mediating adhesion to leukocytes expressing alpha 4 integrins. CD106 plays a crucial role in various physiological and pathological processes. In embryonic development, CD106-deficient mouse embryos are not viable, showing severe defects in placental and heart development. In immune regulation, CD106 is involved in T cell activation and leukocyte recruitment to inflammation sites. It is also critical for mesenchymal stem cells (MSCs)-mediated immunosuppression and the binding of hematopoietic progenitor cells.
流式分析
Flow cytometric analysis of mouse CD106 expression on C57BL/6 mouse bone marrow. C57BL/6 mouse bone marrow were stained with Alexa Fluor® 647 Rat IgG2a, κ Isotype Control (left panel) or SDT Alexa Fluor® 647 Rat Anti-Mouse CD106 Antibody (right panel) at 2 μl/test. Flow cytometry and data analysis were performed using BD FACSymphony™ A1 and FlowJo™ software.
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