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宿主来源
Mouse抗原名称
CD44v6免疫原
Recombinant Protein细胞定位
Cell membraneAccession
NP_001001391.1克隆号
S-945-76抗体类型
Mouse mAb抗体同种型
IgG1,k同型对照
S0B5964反应种属 ?
Hu阳性样本
A431纯化方式
Protein G浓度
0.2 mg/ml标记
Alexa Fluor® 647性状
Liquid缓冲体系
PBS, 1% BSA, 0.3% Proclin 300
储存条件
12 months from date of receipt / reconstitution, 2 to 8 °C as supplied
应用
FCM
稀释度
应用 稀释度 推荐种属 FCM 1.25μl per million cells in 100μl volume Hu
CD44 variable alternative exon 6 (CD44 V6) is a variant isoform of the CD44 gene resulting from alternative splicing of RNA. CD44 is a cell adhesion molecule that is present in various cell types and plays crucial roles in biological processes such as cell migration, proliferation, and differentiation. The CD44 V6 isoform specifically, has been implicated in tumor development and metastasis. Research has shown that CD44v6 is expressed by all colorectal cancer stem cells (CR-CSCs). The expression of CD44v6 is essential for the migration and formation of metastatic tumors, achieved through the activation of the WNT-β-catenin signaling pathway. Propelling evidence recommends that CD44v6 compared to CD44 has a more specific expression in CSCs and may have a higher diagnostic value.
流式分析
Flow cytometric analysis of Human CD44V6 expression on A431 cells. Cells from the A431 (Human epidermoid carcinoma epithelial cell, right) or Raji (Human Burkitt's lymphoma B lymphocyte, left) was stained with either Alexa Fluor® 647 Mouse IgG1, κ Isotype Control (black line histogram) or SDT Alexa Fluor® 647 Mouse Anti-Human CD44v6 Antibody (red line histogram) at 1.25 μl/test. Flow cytometry and data analysis were performed using Agilent NovoCyte Quanteon and FlowJo™ software.
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