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宿主来源
Rat抗原名称
Integrin beta 4分子别名
Integrin beta-4; CD104; Itgb4细胞定位
Cell membraneAccession
A2A863克隆号
S-R716抗体类型
Rat mAb抗体同种型
IgG2a,k同型对照
S0B5537反应种属 ?
Ms阳性样本
bEnd.3纯化方式
Protein G浓度
0.5 mg/ml标记
Alexa Fluor® 488性状
Liquid缓冲体系
PBS, 1% BSA, 0.3% Proclin 300
储存条件
12 months from date of receipt / reconstitution, 2 to 8 °C as supplied
应用
FCM
稀释度
应用 稀释度 推荐种属 FCM 1μg per million cells in 100μl volume Ms
Integrin beta 4 (ITGB4) is a key subunit of the integrin family, primarily functioning as a receptor for laminins and often associating with the alpha 6 subunit to form the α6β4 integrin complex. This transmembrane glycoprotein receptor plays a crucial role in mediating cell-matrix adhesion and signaling, which regulates gene expression, cell growth, and migration. ITGB4 is particularly important in maintaining the stability of hemidesmosomes, which anchor epithelial cells to the basement membrane. Additionally, its expression and activity are implicated in various biological processes, including wound healing, tissue integrity, and cancer progression. Abnormal mutations or dysregulation of ITGB4 have been associated with diseases such as epidermolysis bullosa with pyloric atresia.
流式分析
Flow cytometric analysis of Mouse CD104 expression on bEnd.3 (Mouse brain endothelioma). bEnd.3 were stained with Alexa Fluor® 488 Rat IgG2a, κ Isotype Control (left panel) or SDT Alexa Fluor® 488 Rat Anti-Mouse CD104 Antibody (right panel) at 2 μl/test. The bivariate pseudocolor density plot shows CD104 expression derived from CD4- gated events with the forward and side light-scatter characteristics of viable thymocytes. Flow cytometry and data analysis were performed using Agilent NovoCyte Quanteon and FlowJo™ software.
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