Alexa Fluor^® 647 Mouse Anti-Rat MHC II (RT1D) Antibody (OX-17)

MHC II (RT1D) is a rat major histocompatibility complex class II heterodimeric glycoprotein composed of an α and a β chain that together form an open-ended peptide-binding groove specialized for capturing 12–25 amino-acid fragments derived from exogenous antigens processed through the endocytic pathway; expressed primarily on professional antigen-presenting cells such as B cells, macrophages and dendritic cells, it presents these peptides to CD4⁺ T-helper cells to initiate and shape adaptive immune responses, and in the rat it can be induced by interferon-γ on oligodendroglial progenitor cells, with structural and functional properties that overlap partly with the mouse H2-E and human HLA-DR molecules.