Pacific Blue Mouse Anti-Human CD148 Antibody (S-3121)
Receptor-type tyrosine-protein phosphatase eta,Protein-tyrosine phosphatase eta,R-PTP-eta,Density-enhanced phosphatase 1 (DEP-1),HPTP eta,Protein-tyrosine phosphatase receptor type J (R-PTP-J),DEP1,PTPRJ
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宿主来源
Mouse抗原名称
CD148分子别名
Receptor-type tyrosine-protein phosphatase eta; Protein-tyrosine phosphatase eta; R-PTP-eta; Density-enhanced phosphatase 1 (DEP-1); HPTP eta; Protein-tyrosine phosphatase receptor type J (R-PTP-J); DEP1; PTPRJ细胞定位
Synapse, Secreted, Cell membraneAccession
Q12913克隆号
S-3121抗体类型
Mouse mAb抗体同种型
IgG1,k同型对照
S0B1542反应种属 ?
Hu阳性样本
human peripheral blood Leukocytes纯化方式
Protein G浓度
0.2 mg/ml标记
Pacific Blue性状
Liquid缓冲体系
PBS, 1% BSA, 0.3% Proclin 300
储存条件
12 months from date of receipt / reconstitution, 2 to 8 °C as supplied
应用
FCM
稀释度
应用 稀释度 推荐种属 FCM 5μl per million cells in 100μl volume Hu
CD148 (also called PTPRJ or DEP-1) is a ~220 kDa receptor-type protein tyrosine phosphatase of the R3 subfamily that contains an extracellular region with eight fibronectin III-like repeats, a single transmembrane segment, and an intracellular catalytic domain; it is broadly expressed in hematopoietic and non-hematopoietic cells where it functions as a key negative regulator of growth-factor and adhesion signaling by dephosphorylating receptor tyrosine kinases such as PDGFR, VEGFR, EGFR, and Eph receptors, thereby inhibiting downstream PI3K/AKT, MAPK, and Src-family kinase pathways, promoting contact-inhibited growth, stabilizing cadherin-mediated cell–cell junctions, and acting as a tumor suppressor whose loss or down-regulation is associated with enhanced proliferation, migration, and metastasis in cancers of the stomach, colon, lung, thyroid, and breast.
流式分析
Flow cytometric analysis of CD148 expression on human peripheral blood Leukocytes. human peripheral blood Leukocytes were stained with either Pacific Blue Mouse IgG1, κ Isotype Control (left panel) or Pacific Blue Mouse Anti-Human CD148 Antibody (right panel) at 5 μl/test. Flow cytometry and data analysis were performed using BD FACSymphony™ A1 and FlowJo™ software.
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