Alexa Fluor® 647 Mouse Anti-Human CD244 Antibody (S-2854)
Natural killer cell receptor 2B4,NK cell activation-inducing ligand (NAIL),NK cell type I receptor protein 2B4 (NKR2B4,h2B4),SLAM family member 4 (SLAMF4),Signaling lymphocytic activation molecule 4,2B4
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宿主来源
Mouse抗原名称
CD244分子别名
Natural killer cell receptor 2B4; NK cell activation-inducing ligand (NAIL); NK cell type I receptor protein 2B4 (NKR2B4; h2B4); SLAM family member 4 (SLAMF4); Signaling lymphocytic activation molecule 4; 2B4细胞定位
Cell membraneAccession
Q9BZW8克隆号
S-2854抗体类型
Mouse mAb抗体同种型
IgG2a,k反应种属 ?
Hu阳性样本
Human PBMC纯化方式
Protein A浓度
0.2 mg/ml标记
Alexa Fluor® 647性状
Liquid缓冲体系
PBS, 1% BSA, 0.09% sodium azide
储存条件
12 months from date of receipt / reconstitution, 2 to 8 °C as supplied
应用
FCM
稀释度
应用 稀释度 推荐种属 FCM 5μl per million cells in 100μl volume Hu
CD244, also known as 2B4 or SLAMF4, is a type-I transmembrane protein belonging to the signaling lymphocytic activation molecule (SLAM) family. It is expressed on various immune cells, including NK cells, T cells, monocytes, eosinophils, myeloid-derived suppressor cells, and dendritic cells. CD244 primarily binds to CD48, another member of the SLAM family, to regulate immune responses through both stimulatory and inhibitory signals. Its cytoplasmic domain contains four immunoreceptor tyrosine-based switch motifs (ITSMs) that interact with proteins like SAP, EAT2, and phosphatases to transmit signals. CD244 plays a significant role in immune regulation and has potential as a therapeutic target in diseases such as cancer and autoimmune disorders.
流式分析
Flow cytometric analysis of CD244 expression on human PBMC (human peripheral blood mononuclear cell). Human PBMC were stained with PE Mouse Anti-Human CD56 Antibody and either Alexa Fluor® 647 Mouse IgG2a, k Isotype Control (left panel) or Alexa Fluor® 647 Mouse Anti-Human CD244 antibody (right panel) at 5 μl/test. Flow cytometry and data analysis were performed using Agilent NovoCyte Quanteon and FlowJo™ software.
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