Alexa Fluor® 488 Mouse Anti-Human CD271 Antibody (S-2902)
Tumor necrosis factor receptor superfamily member 16,Gp80-LNGFR,Low affinity neurotrophin receptor p75NTR,Low-affinity nerve growth factor receptor (NGF receptor),Low-affinity nerve growth factor receptor p75NGFR,Low-affinity nerve growth factor receptor p75NGR,p75 ICD,TNFRSF16,NGFR
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宿主来源
Mouse抗原名称
CD271分子别名
Tumor necrosis factor receptor superfamily member 16; Gp80-LNGFR; Low affinity neurotrophin receptor p75NTR; Low-affinity nerve growth factor receptor (NGF receptor); Low-affinity nerve growth factor receptor p75NGFR; Low-affinity nerve growth factor receptor p75NGR; p75 ICD; TNFRSF16; NGFR细胞定位
Cytoplasm, Cell membraneAccession
P08138克隆号
S-2902抗体类型
Mouse mAb抗体同种型
IgG1,k同型对照
S0B1519反应种属 ?
Hu阳性样本
SH-SY5Y纯化方式
Protein G浓度
0.2 mg/ml标记
Alexa Fluor® 488性状
Liquid缓冲体系
PBS, 1% BSA, 0.09% sodium azide
储存条件
12 months from date of receipt / reconstitution, 2 to 8 °C as supplied
应用
FCM
稀释度
应用 稀释度 推荐种属 FCM 5μl per million cells in 100μl volume Hu
CD271 (also termed p75NTR or NGFR) is a low-affinity neurotrophin receptor that functions as a context-dependent molecular switch, promoting either differentiation and apoptosis in normal tissues or survival, stemness and metastasis in cancers by activating MEK/ERK, RhoA/ROCK and other downstream cascades, and its expression marks therapy-resistant melanoma-initiating cells, drives phenotype switching in cutaneous squamous cell carcinoma, correlates with aggressive disease in medulloblastoma and neurofibromatosis tumors, and orchestrates osteogenic commitment of ectomesenchymal stem cells during craniofacial bone development.
流式分析
SH-SY5Y (human neuroblastoma epithelial cell) were stained with either Alexa Fluor® 488 Mouse IgG1, κ Isotype Control (black line histogram) or Alexa Fluor® 488 Mouse anti-Human CD271 Antibody (red line histogram) at 5μl/test. Flow cytometry and data analysis were performed using BD FACSymphony™ A1 and FlowJo™ software.
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