Alexa Fluor^® 488 Mouse Anti-Human CCR10 Antibody (S-4710)

The CCR10 protein (C-C motif chemokine receptor 10) is a G protein-coupled receptor primarily expressed on the surface of skin T cells, IgA plasmablasts, and various skin structural cells (such as fibroblasts and melanocytes). It primarily regulates the specific migration (homing) of lymphocytes to the skin and mucosal tissues such as the intestine and lungs by binding to its ligands, CCL27 (highly expressed in keratinocytes) and CCL28 (highly expressed in mucosal epithelial cells). This receptor plays a critical role in maintaining skin immune homeostasis, promoting wound healing, and mediating the localization of IgA-secreting cells to mucosal sites such as the mammary gland. However, its function is highly context-dependent: in inflammatory diseases such as psoriasis and atopic dermatitis, CCR10 can both mediate the skin infiltration of pathogenic T cells and help limit excessive inflammatory responses. In cancers such as melanoma, it may also be exploited by tumor cells to achieve immune evasion and metastasis.