Mouse Anti-Human CD26 Antibody (M-A261)

CD26, also known as dipeptidyl peptidase-4 (DPP-4), is a widely expressed type II transmembrane glycoprotein that functions primarily as a serine exopeptidase responsible for cleaving N-terminal dipeptides from polypeptides containing proline or alanine at the penultimate position, thereby playing a critical regulatory role in glucose homeostasis by inactivating incretin hormones such as glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP). Beyond its enzymatic activity, CD26 serves as a multifunctional cell surface receptor involved in various physiological and pathological processes, including T-cell activation, immune regulation, apoptosis, and tumor progression, and it notably acts as the primary cellular receptor for certain coronaviruses, facilitating viral entry into host cells. Due to its pivotal role in degrading incretins, CD26 has become a major therapeutic target in the management of type 2 diabetes, with DPP-4 inhibitors (gliptins) widely used to enhance endogenous insulin secretion and lower blood glucose levels, while ongoing research continues to explore its implications in cancer biology, immunology, and infectious diseases.