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宿主来源
Mouse抗原名称
CD192分子别名
C-C chemokine receptor type 2; C-C CKR-2; CC-CKR-2; CCR-2; CCR2; Monocyte chemoattractant protein 1 receptor (MCP-1-R); CMKBR2细胞定位
Cell membraneAccession
P41597克隆号
S-2971抗体类型
Mouse mAb抗体同种型
IgG2a,k反应种属 ?
Hu阳性样本
human PBMC纯化方式
Protein A浓度
0.2 mg/ml标记
Alexa Fluor® 488性状
Liquid缓冲体系
PBS, 1% BSA, 0.09% sodium azide
储存条件
12 months from date of receipt / reconstitution, 2 to 8 °C as supplied
应用
FCM
稀释度
应用 稀释度 推荐种属 FCM 5μl per million cells in 100μl volume Hu
CD192, also called CCR2, is a 42 kDa seven-transmembrane G-protein-coupled receptor expressed mainly on monocytes, macrophages and basophils that binds the chemokines MCP-1 (CCL2), MCP-3 (CCL7) and MCP-4 (CCL13), triggers intracellular calcium flux and inhibition of adenylyl cyclase, thereby directing chemotaxis and bone marrow homeostasis, and has been implicated in inflammatory diseases such as rheumatoid arthritis, atherosclerosis and cancer as well as serving as an alternative HIV-1 coreceptor with CD4.
流式分析
Flow cytometric analysis of human CD192 expression on human PBMC (human peripheral blood mononuclear cell). Human PBMC were stained with Brilliant Violet 421™ Mouse Anti-Human CD14 Antibody and either Alexa Fluor® 488 Mouse IgG2a, k Isotype Control (left panel) or SDT Alexa Fluor® 488 Mouse Anti-Human CD192 Antibody (right panel) at 5 μl/test. Flow cytometry and data analysis were performed using Agilent NovoCyte Quanteon and FlowJo™ software.
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