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宿主来源
Mouse抗原名称
CD191分子别名
C-C chemokine receptor type 1; C-C CKR-1; CC-CKR-1; CCR-1; CCR1; HM145; LD78 receptor; Macrophage inflammatory protein 1-alpha receptor (MIP-1alpha-R); RANTES-R; CMKBR1; CMKR1; SCYAR1细胞定位
Cell membraneAccession
P32246克隆号
S-3286抗体类型
Mouse mAb抗体同种型
IgG1,k反应种属 ?
Hu阳性样本
Human PBMC纯化方式
Protein G浓度
0.2 mg/ml标记
Alexa Fluor® 488性状
Liquid缓冲体系
PBS, 1% BSA, 0.09% sodium azide
储存条件
12 months from date of receipt / reconstitution, 2 to 8 °C as supplied
应用
FCM
稀释度
应用 稀释度 推荐种属 FCM 5μl per million cells in 100μl volume Hu
CD191 (officially designated CD191, also termed C-C chemokine receptor type 1, CCR1) is a 41 kDa seven-transmembrane G-protein-coupled receptor encoded by the CCR1 gene on chromosome 3p; it is predominantly expressed on monocytes, granulocytes, and a subset of T cells, where it binds the CC chemokines CCL3 (MIP-1α), CCL5 (RANTES), CCL7 (MCP-3) and CCL23 (MPIF-1) to trigger intracellular signaling that mediates chemotactic recruitment of effector leukocytes to inflammatory sites, thereby playing key roles in host defense against infection, regulation of inflammatory responses, and susceptibility to viral and parasitic pathogens.
流式分析
Flow cytometric analysis of human CD191 expression on human PBMC. Human PBMC were stained with Brilliant Violet 421™ Mouse Anti-Human CD14 Antibody and either Alexa Fluor® 488 Mouse IgG1, κ Isotype Control (left panel) or SDT Alexa Fluor® 488 Mouse Anti- Human CD191 antibody (right panel) at 5 μl/test. Flow cytometry and data analysis were performed using Agilent NovoCyte Quanteon and FlowJo™ software.
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