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宿主来源
Armenian hamster抗原名称
CD194分子别名
C-C chemokine receptor type 4; C-C CKR-4; CC-CKR-4; CCR-4; CCR4; Cmkbr4细胞定位
Cell membraneAccession
P51680克隆号
S-R694抗体类型
Recombinant mAb抗体同种型
IgG反应种属 ?
Ms阳性样本
BALB/c mouse thymocytes纯化方式
Protein G浓度
0.5 mg/ml标记
Alexa Fluor® 488性状
Liquid缓冲体系
PBS, 1% BSA, 0.09% sodium azide
储存条件
12 months from date of receipt / reconstitution, 2 to 8 °C as supplied
应用
FCM
稀释度
应用 稀释度 推荐种属 FCM 0.25μg per million cells in 100μl volume Ms
CD194, also known as CCR4 (C-C chemokine receptor type 4), is a G protein-coupled receptor with seven transmembrane domains. It is expressed on various immune cells, including CD4+ T cells (especially Th2 cells), regulatory T cells (Tregs), basophils, monocytes, and natural killer (NK) cells. CCR4 binds to chemokines such as CCL17 (TARC) and CCL22 (MDC), playing a crucial role in the recruitment of memory T cells and immune responses in conditions like atopic dermatitis and asthma. Additionally, CCR4 is involved in tumor biology, with high expression levels associated with tumor infiltration and prognosis in both hematological malignancies and solid tumors, making it a potential target for cancer immunotherapy.
流式分析
Flow cytometric analysis of mouse CD194 expression on BALB/c mouse thymocytes. BALB/c mouse thymocytes were stained with Brilliant Violet 421™ Rat Anti-Mouse CD4 Antibody and either Alexa Fluor® 488 Armenian hamster IgG Isotype Control (left panel) or SDT Alexa Fluor® 488 Armenian hamster Anti-Mouse CD194 Antibody (right panel) at 0.5 μl/test. Flow cytometry and data analysis were performed using BD FACSymphony™ A1 and FlowJo™software.
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