Rat Anti-Human/Mouse CLA Antibody (S-R679)

CD42a, also known as glycoprotein IX (GPIX), is a small, single-pass transmembrane glycoprotein expressed on platelets and megakaryocytes that non-covalently associates with glycoproteins Ibα, Ibβ, and V to form the GPIb-V-IX complex, which acts as the platelet receptor for von Willebrand factor (vWF), enabling vWF-dependent platelet adhesion to injured vessel walls and initiating arterial hemostasis; CD42a contains leucine-rich repeats, is encoded by GP9 on chromosome 3q21.3, and mutations in this gene cause Bernard–Soulier syndrome, a bleeding disorder characterized by giant platelets and impaired aggregation.