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宿主来源
Mouse抗原名称
CD126分子别名
Interleukin-6 receptor subunit alpha; IL-6 receptor subunit alpha; IL-6R subunit alpha; IL-6R-alpha; IL-6RA; IL-6R 1; Membrane glycoprotein 80 (gp80); IL6R细胞定位
Cell membraneAccession
P08887克隆号
S-2911抗体类型
Mouse mAb抗体同种型
IgG1,k反应种属 ?
Hu阳性样本
human peripheral blood lymphocytes纯化方式
Protein G浓度
0.2 mg/ml标记
Biotin性状
Liquid缓冲体系
PBS pH7.4, 0.03% Proclin 300
储存条件
12 months from date of receipt / reconstitution, 2 to 8 °C as supplied
应用
FCM
稀释度
应用 稀释度 推荐种属 FCM 5μl per million cells in 100μl volume Hu
CD126, also known as the interleukin-6 receptor alpha chain (IL-6Rα), is a type I cytokine receptor that plays a crucial role in regulating cell growth and differentiation in various tissues. It is a subunit of the IL-6 receptor complex, which also includes the signal-transducing subunit glycoprotein 130 (gp130 or CD130). CD126 is primarily expressed on B cells, epithelial cells, and hepatocytes. The binding of IL-6 to CD126 forms a complex that, in association with CD130, initiates signaling pathways involved in immune responses and acute phase reactions. Dysregulated production of IL-6 and CD126 is implicated in the pathogenesis of several diseases, including multiple myeloma, autoimmune diseases, and certain cancers. Additionally, CD126 is being explored as a potential therapeutic target for CAR-T cell therapy due to its expression in various tumors.
流式分析
Flow cytometric analysis of human CD126 expression on human peripheral blood lymphocytes. Human peripheral blood lymphocytes were stained with Brilliant Violet 421™ Mouse Anti-Human CD3 Antibody and either Biotin IgG1, κ Isotype Control (left panel) or SDT Biotin Mouse Anti-Human CD126 Antibody (right panel) at 5μl/test followed by Sav-PE. Flow cytometry and data analysis were performed using Agilent NovoCyte Quanteon and FlowJo™ software.
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