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宿主来源
Mouse抗原名称
CD158b/j分子别名
CD158b1; KIR2DL2; CD158B1; NKAT2a; NKAT2b; CD158b2; KIR2DL3; CD158B2; KIRCL23; NKAT2; CD158j; KIR2DS2; CD158J; NKAT5细胞定位
Cell membraneAccession
P43627克隆号
S-2917抗体类型
Mouse mAb抗体同种型
IgG2a,k反应种属 ?
Hu阳性样本
human peripheral blood lymphocytes纯化方式
Protein A浓度
0.2 mg/ml标记
Biotin性状
Liquid缓冲体系
PBS pH7.4, 0.03% Proclin 300
储存条件
12 months from date of receipt / reconstitution, 2 to 8 °C as supplied
应用
FCM
稀释度
应用 稀释度 推荐种属 FCM 5μl per million cells in 100μl volume Hu
CD158b/j, also known as KIR2DL2/L3/S2, is a member of the killer cell immunoglobulin-like receptor (KIR) family and belongs to the immunoglobulin superfamily. It is a type I membrane glycoprotein with two immunoglobulin C2-type domains. CD158b/j is expressed on natural killer (NK) cells and a subset of T cells. These receptors play a crucial role in modulating the immune response by interacting with specific HLA-C antigens on target cells, thereby inhibiting the cytotoxic functions of NK and T cells. The expression of CD158b/j on T cells increases with age, particularly in CD8 T cells, due to epigenetic changes such as DNA demethylation. This age-related expression pattern may contribute to the immune senescence observed in older individuals.
流式分析
Flow cytometric analysis of human CD158bj expression on human peripheral blood lymphocytes. Human peripheral blood lymphocytes were stained with PE Mouse Anti-Human CD56 Antibody and either Biotin Mouse IgG2a, κ Isotype Control (left panel) or SDT Biotin Mouse Anti-Human CD158bj Antibody (right panel) at 5 μl/test followed by Sav-iFluor 488. Flow cytometry and data analysis were performed using Agilent NovoCyte Quanteon and FlowJo™ software.
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