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宿主来源
Mouse抗原名称
CD147分子别名
Basigin; 5F7; Collagenase stimulatory factor; Extracellular matrix metalloproteinase inducer (EMMPRIN); Hepatoma-associated antigen (HAb18G); Leukocyte activation antigen M6; BSG细胞定位
Endosome, Cell membrane, Endoplasmic reticulumAccession
P35613克隆号
S-2803抗体类型
Mouse mAb抗体同种型
IgG1,k反应种属 ?
Hu阳性样本
Human peripheral blood cells纯化方式
Protein G浓度
0.2 mg/ml标记
Alexa Fluor® 647性状
Liquid缓冲体系
PBS, 1% BSA, 0.3% Proclin 300
储存条件
12 months from date of receipt / reconstitution, 2 to 8 °C as supplied
应用
FCM
稀释度
应用 稀释度 推荐种属 FCM 5μl per million cells in 100μl volume Hu
CD147, also known as EMMPRIN (extracellular matrix metalloproteinase inducer) or basigin, is a transmembrane glycoprotein and a member of the immunoglobulin superfamily. It is widely expressed in various tissues and cells and plays a crucial role in multiple physiological and pathological processes. CD147 is best known for its ability to induce the expression of matrix metalloproteinases (MMPs), which are involved in extracellular matrix remodeling, tumor invasion, and metastasis. It also regulates glycolysis and is associated with the Warburg effect in cancer cells, promoting tumor growth and resistance to therapy. Additionally, CD147 is involved in inflammation, immune responses, and the pathogenesis of diseases such as asthma, rheumatoid arthritis, and myocardial infarction. In neurological contexts, it contributes to processes ranging from normal retinal function to neuroinflammation in Alzheimer's disease. Its diverse functions and wide expression make it a promising target for therapeutic interventions in various diseases.
流式分析
Flow cytometric analysis of human CD147 expression on human peripheral blood cells. Human peripheral blood cells were stained with Alexa Fluor® 647 Mouse IgG1, k Isotype Control (left panel) or SDT Alexa Fluor® 647 Mouse Anti-Human CD147 Antibody (right panel) at 5 μl/test. Flow cytometry and data analysis were performed using BD FACSymphony™ A1 and FlowJo™ software.
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