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宿主来源
Armenian hamster抗原名称
CD27分子别名
CD27 antigen; CD27L receptor; T-cell activation antigen CD27; T14; Tumor necrosis factor receptor superfamily member 7Imported; TNFRSF7细胞定位
Cell membraneAccession
P26842, P41272, Q501W2克隆号
S-R620抗体类型
Recombinant mAb抗体同种型
IgG反应种属 ?
Hu, Ms, Rt阳性样本
Human PBMC纯化方式
Protein G浓度
0.2 mg/ml标记
PE-Cy7性状
Liquid缓冲体系
PBS, 1% BSA, 0.3% Proclin 300
储存条件
12 months from date of receipt / reconstitution, 2 to 8 °C as supplied
应用
FCM
稀释度
应用 稀释度 推荐种属 FCM 5μl per million cells in 100μl volume Hu, Ms, Rt
CD27 protein is a member of the tumor necrosis factor (TNF) receptor superfamily. It is expressed on the surface of various immune cells such as T cells and B cells. CD27 can interact with its ligand CD70, which is mainly found on antigen - presenting cells (APCs) and activated T cells. This interaction plays a crucial role in the regulation of immune responses. It can promote T cell proliferation and differentiation, enhance the cytotoxic activity of T cells against infected or cancerous cells, and also participate in the regulation of B cell functions such as immunoglobulin production. Moreover, the CD27 - CD70 pathway is involved in the development and maintenance of immune memory, helping the immune system to remember and respond more effectively to pathogens it has previously encountered. Abnormal expression or function of CD27 has been implicated in certain immune - related diseases and cancers, making it a potential target for therapeutic interventions in these conditions.
流式分析
Flow cytometric analysis of CD27 expression on Human PBMC. Human PBMC (peripheral blood mononuclear cells) were stained with Brilliant Violet 421™ Mouse Anti-Human CD3 Antibody and either PE-Cy7 Armenian hamster IgG Isotype Control (Left panel) or PE-Cy7 Armenian hamster Anti-Mouse/Rat/Human CD27 Antibody (Right panel) at 5 μl/test treated with True-Stain Monocyte Blocker™. Flow cytometry and data analysis were performed using BD FACSymphony™ A1 and FlowJo™ software.
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