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宿主来源
Mouse抗原名称
CD180分子别名
CD180 antigen; Lymphocyte antigen 64; Radioprotective 105 kDa protein; LY64; RP105细胞定位
Cell membraneAccession
Q99467克隆号
S-2904抗体类型
Mouse mAb抗体同种型
IgG1,k反应种属 ?
Hu阳性样本
human PBMC纯化方式
Protein G浓度
0.2 mg/ml标记
Pacific Blue性状
Liquid缓冲体系
PBS, 1% BSA, 0.3% Proclin 300
储存条件
12 months from date of receipt / reconstitution, 2 to 8 °C as supplied
应用
FCM
稀释度
应用 稀释度 推荐种属 FCM 5μl per million cells in 100μl volume Hu
CD180, also known as RP105, is a cell-surface glycoprotein of the Toll-like receptor (TLR) family that consists of extracellular leucine-rich repeats and a short cytoplasmic tail, and, when paired with its accessory molecule MD-1, forms the RP105/MD-1 receptor complex that collaborates with TLR4 to recognize bacterial lipopolysaccharide and regulate innate immune signaling in B cells, leading to NF-κB activation, control of B-cell proliferation, and modulation of life-or-death decisions, while its dysfunction is implicated in diseases such as chronic lymphocytic leukemia and Kawasaki disease.
流式分析
Flow cytometric analysis of human CD180 expression on human PBMC (human peripheral blood mononuclear cell). Human PBMC were stained with APC Mouse Anti-Human CD19 Antibody and either Pacific Blue Mouse IgG1, k Isotype Control (left panel) or SDT Pacific Blue Mouse Anti-Human CD180 Antibody (right panel) at 5 μl/test. Flow cytometry and data analysis were performed using BD FACSymphony™ A1 and FlowJo™ software.
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