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宿主来源
Mouse抗原名称
CD11a分子别名
Integrin alpha-L; CD11 antigen-like family member A; Leukocyte adhesion glycoprotein LFA-1 alpha chain (LFA-1A); Leukocyte function-associated molecule 1 alpha chain; CD11A; ITGAL细胞定位
Cell membraneAccession
P20701克隆号
HI111抗体类型
Mouse mAb抗体同种型
IgG1,k反应种属 ?
Hu阳性样本
Human peripheral blood Leukocytes纯化方式
Protein G浓度
0.2 mg/ml标记
PE-Cy7性状
Liquid缓冲体系
PBS, 1% BSA, 0.3% Proclin 300
储存条件
12 months from date of receipt / reconstitution, 2 to 8 °C as supplied
应用
FCM
稀释度
应用 稀释度 推荐种属 FCM 1.25μl per million cells in 100μl volume Hu
CD11a, also known as integrin alpha L, is a protein encoded by the ITGAL gene in humans and is a critical component of the leukocyte function-associated antigen-1 (LFA-1) complex, which is essential for immune cell adhesion and signaling. It pairs with CD18 to form LFA-1, a heterodimeric transmembrane protein that mediates interactions between leukocytes and other cells, such as T cells and antigen-presenting cells. This interaction is crucial for leukocyte migration to sites of inflammation and the formation of immunological synapses. CD11a is expressed on all leukocytes and plays a key role in immune surveillance and inflammatory responses. It is also a target for therapeutic agents like efalizumab, which was used to treat psoriasis by inhibiting the interaction between LFA-1 and its ligands, such as ICAM-1.
流式分析
Flow cytometric analysis of Human CD11a expression on human peripheral blood Leukocytes. Human peripheral blood Leukocytes were stained with either PE-Cy7 Mouse IgG1, κ Isotype Control (Black line histogram) or SDT PE-Cy7 Mouse Anti-Human CD11a antibody (Red line histogram) at 1.25 μl/test treated with True-Stain Monocyte Blocker™, cells without incubation with primary antibody and secondary antibody (Blue line histogram) was used as unlabelled control. Flow cytometry and data analysis were performed using BD FACSymphony™ A1 and FlowJo™ software.
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