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宿主来源
Mouse抗原名称
CD183分子别名
C-X-C chemokine receptor type 3; CXC-R3; CXCR-3; CKR-L2; G protein-coupled receptor 9; Interferon-inducible protein 10 receptor (IP-10 receptor); GPR9; CXCR3细胞定位
Cell membraneAccession
P49682克隆号
S-R583抗体类型
Mouse mAb抗体同种型
IgG1,k反应种属 ?
Hu阳性样本
Human PBMC纯化方式
Protein G浓度
0.2 mg/ml标记
Biotin性状
Liquid缓冲体系
PBS pH7.4, 0.03% Proclin 300
储存条件
12 months from date of receipt / reconstitution, 2 to 8 °C as supplied
应用
FCM
稀释度
应用 稀释度 推荐种属 FCM 5μl per million cells in 100μl volume Hu
CD183, also known as CXCR3, is a 38–41 kD seven-transmembrane G-protein coupled receptor that belongs to the C-X-C chemokine receptor family. It is highly expressed on T cells (Th1), natural killer cells, dendritic cells, mast cells, alveolar macrophages, and some B cells. CXCR3 binds to three chemokines: CXCL9 (MIG), CXCL10 (IP-10), and CXCL11 (I-TAC), and plays a crucial role in mediating chemotaxis and cell proliferation in immune responses. It is involved in the recruitment of inflammatory cells to sites of inflammation and is associated with various inflammatory and autoimmune diseases. Additionally, CXCR3 has different isoforms, such as CXCR3A, CXCR3B, and CXCR3-alt, each with distinct functions.
流式分析
Flow cytometric analysis of human CD183 expression on human PBMC. Human PBMC (peripheral blood mononuclear cells) were stained with Alexa Fluor® 647 Mouse Anti-Human CD3 Antibody and either Biotin Mouse IgG1, k Isotype Control (left panel) or Biotin Mouse Anti-Human CD183 Antibody (right panel) at 5 μl/test followed by Sav-iFluor 488. Flow cytometry and data analysis were performed using Agilent NovoCyte Quanteon and FlowJo™ software.
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