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宿主来源
Mouse抗原名称
CD137分子别名
Tumor necrosis factor receptor superfamily member 9; 4-1BB ligand receptor; CDw137; T-cell antigen 4-1BB homolog; T-cell antigen ILA; ILA; TNFRSF9细胞定位
Cell membraneAccession
Q07011克隆号
4B4-1抗体类型
Mouse mAb抗体同种型
IgG1,k反应种属 ?
RhMk, CyMk, Hu阳性样本
PHA-activated human PBMC纯化方式
Protein G浓度
0.2 mg/ml标记
Biotin性状
Liquid缓冲体系
PBS pH7.4, 0.03% Proclin 300
储存条件
12 months from date of receipt / reconstitution, 2 to 8 °C as supplied
应用
FCM
稀释度
应用 稀释度 推荐种属 FCM 1.25μl per million cells in 100μl volume Hu
CD137, also known as 4-1BB, is a co-stimulatory molecule expressed on the surface of activated T cells and natural killer cells. It plays a crucial role in enhancing the immune response by providing additional signals that promote T cell proliferation, survival, and cytokine production. CD137 is a member of the tumor necrosis factor receptor superfamily and its ligand, CD137L, is primarily found on antigen-presenting cells. The interaction between CD137 and CD137L helps to sustain the activation of T cells and supports the development of long-lasting immune responses, making it an important target for immunotherapy in cancer treatment and other diseases where modulation of the immune system is beneficial.
流式分析
Flow cytometric analysis of CD137 expression in activated human PBMC (human peripheral blood mononuclear cell). PHA-activated (2 days) human PBMC were stained with Brilliant Violet 421™ Mouse Anti-Human CD25 Antibody and either Biotin Mouse IgG1, k Isotype Control (left panel) or SDT Biotin Mouse Anti-Human CD137 Antibody (right panel) at 1.25 μl/test followed by Sav-iFluor 488. Flow cytometry and data analysis were performed using BD FACSymphony™ A1 and FlowJo™ software
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