Syrian hamster Anti-Mouse/Human KLRG-1 Antibody (S-3757)
Killer cell lectin-like receptor subfamily G member 1,C-type lectin domain family 15 member A,ITIM-containing receptor MAFA-L,MAFA-like receptor,Mast cell function-associated antigen,CLEC15A,MAFA,MAFAL,KLRG1
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宿主来源
Syrian Hamster抗原名称
KLRG1分子别名
Killer cell lectin-like receptor subfamily G member 1; C-type lectin domain family 15 member A; ITIM-containing receptor MAFA-L; MAFA-like receptor; Mast cell function-associated antigen; CLEC15A; MAFA; MAFAL; KLRG1细胞定位
Cell membraneAccession
Q96E93, O88713克隆号
S-3757抗体类型
Recombinant mAb抗体同种型
IgG反应种属 ?
Hu, Ms阳性样本
C57BL/6 mouse splenocytes纯化方式
Protein G浓度
2 mg/ml标记
Unconjugated性状
Liquid缓冲体系
PBS pH7.4
储存条件
12 months from date of receipt / reconstitution, 2 to 8 °C as supplied
应用
FCM
稀释度
应用 稀释度 推荐种属 FCM 1:100 Hu, Ms
Killer cell lectin-like receptor G1 (KLRG1) is a 30–35 kDa C-type lectin-like inhibitory receptor expressed predominantly on the surface of late-differentiated effector and effector-memory CD8⁺ T, NK, NKT and some CD4⁺ T cells, where its engagement by ubiquitous E-, N- or R-cadherins on epithelial or vascular structures delivers SHP-1/2-dependent signals that terminate calcium flux, cytotoxic granule release and proliferation, thereby acting as a crucial “brake” on acute and chronic immune responses; up-regulated by repeated antigen or IL-2/IL-15 stimulation, KLRG1 demarcates short-lived effector cells destined for apoptosis versus long-lived memory precursors, and its genetic or antibody blockade enhances viral clearance, tumor control and vaccine efficacy, while its sustained expression correlates with T-cell exhaustion, immunosenescence and impaired survival in infections, cancer and autoimmunity, positioning KLRG1 as a key biomarker and therapeutic target for immune rejuvenation.
流式分析
Flow cytometric analysis of C57BL/6 mouse splenocytes labeled KLRG1 antibody at 1/100 dilution (2 μg) / (right panel) compared with a Syrian Hamster IgG Isotype Control / (left panel). Goat Anti- Syrian Hamster IgG Alexa Fluor® 488 was used as the secondary antibody. Then cells were stained with NK1.1 - Alexa Fluor® 647 antibody separately. Flow cytometry and data analysis were performed using Agilent NovoCyte Quanteon and FlowJo™ software.
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